Red cell folate (categories 3)
Red cell folate data available for STOP cohort only.
Over or below median (median level calculated in STOP) <14900 vs ≥14900.
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
178.181094
|
1
|
<0.0001
|
***
|
|
rcfolate_gp3
|
1.581702
|
1
|
0.2
|
ns
|
|
GA_samp
|
72.949708
|
1
|
<0.0001
|
***
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
41.6216409
|
1
|
<0.0001
|
***
|
|
rcfolate_gp3
|
0.2280064
|
1
|
0.6
|
ns
|
|
GA_samp
|
1128.5376199
|
1
|
<0.0001
|
***
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
423.138396
|
1
|
<0.0001
|
***
|
|
rcfolate_gp3
|
2.101071
|
1
|
0.1
|
ns
|
|
GA_samp
|
564.814742
|
1
|
<0.0001
|
***
|
Insulin (uU/ml)
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
rcfolate_gp3
|
1
|
Inf
|
0.807
|
0.807
|
0.4
|
ns
|
|
GA_samp
|
1
|
Inf
|
0.589
|
0.589
|
0.4
|
ns
|
HOMA-IR
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
rcfolate_gp3
|
1
|
Inf
|
0.947
|
0.947
|
0.3
|
ns
|
|
GA_samp
|
1
|
Inf
|
0.448
|
0.448
|
0.5
|
ns
|
Glucose (mmol/L)
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
rcfolate_gp3
|
1
|
Inf
|
4.497
|
4.497
|
0.03
|
*
|
|
GA_samp
|
1
|
Inf
|
0.987
|
0.987
|
0.3
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
14.79 (9.96, 21.95)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
1.07 (0.96, 1.19)
|
0.21
|
|
GA_samp
|
1.15 (1.11, 1.19)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.99 (1.61, 2.45)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
0.99 (0.93, 1.05)
|
0.63
|
|
GA_samp
|
1.35 (1.33, 1.37)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.05 (0.04, 0.06)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
0.94 (0.87, 1.02)
|
0.15
|
|
GA_samp
|
1.35 (1.32, 1.39)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
8.31 (5.12, 13.46)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
1.06 (0.93, 1.22)
|
0.37
|
|
GA_samp
|
1.02 (0.97, 1.06)
|
0.44
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.77 (1.07, 2.92)
|
0.03
|
|
rcfolate_gp3≥14900
|
1.07 (0.93, 1.23)
|
0.33
|
|
GA_samp
|
1.02 (0.97, 1.06)
|
0.50
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
4.85 (4.43, 5.32)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
1.04 (1.00, 1.08)
|
0.03
|
|
GA_samp
|
1.00 (0.99, 1.00)
|
0.32
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

Estimated marginal means
|
Outcome
|
rcfolate_gp3
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
PRL (ng/ml)
|
<14900
|
72.355
|
6.142
|
71.241
|
61.089
|
85.700
|
|
PRL (ng/ml)
|
≥14900
|
77.551
|
6.690
|
75.947
|
65.309
|
92.088
|
|
hPL (μg/ml)
|
<14900
|
62.766
|
2.027
|
66.301
|
58.847
|
66.946
|
|
hPL (μg/ml)
|
≥14900
|
61.863
|
2.073
|
76.512
|
57.870
|
66.131
|
|
GH2 (ng/ml)
|
<14900
|
1.490
|
0.059
|
82.604
|
1.377
|
1.612
|
|
GH2 (ng/ml)
|
≥14900
|
1.401
|
0.058
|
97.719
|
1.290
|
1.522
|
|
Insulin (uU/ml)
|
<14900
|
10.044
|
0.430
|
Inf
|
9.236
|
10.923
|
|
Insulin (uU/ml)
|
≥14900
|
10.679
|
0.565
|
Inf
|
9.628
|
11.845
|
|
HOMA-IR
|
<14900
|
2.098
|
0.094
|
Inf
|
1.922
|
2.290
|
|
HOMA-IR
|
≥14900
|
2.250
|
0.126
|
Inf
|
2.016
|
2.511
|
|
Glucose (mmol/L)
|
<14900
|
4.657
|
0.048
|
Inf
|
4.564
|
4.753
|
|
Glucose (mmol/L)
|
≥14900
|
4.844
|
0.074
|
Inf
|
4.700
|
4.992
|
Post-hoc comparisons
|
Outcome
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥14900 / <14900
|
1.07 (0.96, 1.19)
|
0.2
|
|
hPL (μg/ml)
|
≥14900 / <14900
|
0.99 (0.93, 1.05)
|
0.6
|
|
GH2 (ng/ml)
|
≥14900 / <14900
|
0.94 (0.87, 1.02)
|
0.1
|
|
Insulin (uU/ml)
|
≥14900 / <14900
|
1.06 (0.93, 1.22)
|
0.4
|
|
HOMA-IR
|
≥14900 / <14900
|
1.07 (0.93, 1.23)
|
0.3
|
|
Glucose (mmol/L)
|
≥14900 / <14900
|
1.04 (1.00, 1.08)
|
0.03
|